Leeds have knocked Quins out of the Cup four times in the last eight seasons. Quins won at Headingley Carnegie in Round 3 of the 2011 Super League against their former boss Brian McDermott.
The draw in full is:
Huddersfield v Catalan Dragons
Warrington v Swinton
Leeds v Harlequins
St Helens v Featherstone
Wakefield v Castleford
Bradford v Wigan
Widnes v Hull
Salford v Hull KR
Ties to be played on the weekend of May 21-22.
