The four missing players are centre Steve Bell and forwards Mark Bryant and Steve Menzies, who have all joined Super League clubs, and prop Brent Kite, who remained in Australia on compassionate leave.
Jason King is promoted in the front row in place of Kite, with George Rose set to make his comeback from an 18-month lay-off with a double fracture of his leg.
"George has worked really hard after his horrific injury and deserves his spot," Manly coach Des Hasler told a news conference at Leeds Met University.
A positional change sees former St Helens centre Jamie Lyon revert to his normal position from stand-off, where ex-Newcastle Knights player Chris Bailey - younger brother of Wigan centre Phil - will make his debut.
The side includes winger Michael Robertson, who scored a hat-trick of tries in the Sea Eagles' 40-0 win over Melbourne in October and went on to play for Scotland in the World Cup.
Team: B Stewart; Robertson, Lyon, Matai, Williams; Bailey, Orford (capt); King, Ballin, Perry, Watmough, Hall, G Stewart. Subs (from): L'Estrange, Cuthbertson, Rose, Rodney, Waerea-Hargreaves.

































